A recent study reveals that taking both PDE5i medicines for erectile dysfunction and nitroglycerin consumption for chest pain increase the chance of early mortality.
It’s crucial to remember that this is only one study, and more research is needed to confirm the findings and better understand the underlying mechanisms.
Here’s what we know so far.
PDE5i inhibitors, including sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra), function by boosting blood flow to the penis.
Nitroglycerin, relieves chest pain (angina) by relaxing and expanding blood vessels.
Journal of the American College of Cardiology, examined data from over 60,000 men who had a history of both erectile dysfunction and cardiovascular disease.
The study, published in the Journal of the American College of Cardiology, examined data from over 60,000 men who had a history of both erectile dysfunction and cardiovascular disease.
Medical researchers discovered that men who take both PDE5i medicines and nitrates have a higher chance of dying from any cause during the follow-up period than men who take only one of these prescriptions or none at all.
The study, which was conducted over a long period, revealed that the combination of these drugs can cause a variety of health issues, some of which are fatal.
PDE5i medicines, such as sildenafil and tadalafil, are frequently administered to men suffering from erectile dysfunction, while nitrates are used to treat disorders like angina.
The combination of these medicines can induce a significant reduction in blood pressure.
The combination of these medicines can induce a significant reduction in blood pressure, resulting in a variety of problems, including heart attacks, strokes, and even death.
Men who are prescribed these prescriptions must inform their healthcare provider of any other medications they are taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid any drug interactions that could be damaging to their health.
While PDE5i medicines and nitrates can be beneficial in treating specific medical issues, it is critical to adhere to the specified dosage and avoid self-medication or drug combinations without competent medical supervision.
Men must prioritize their health and well-being by consulting a doctor before taking any drug and following the suggested instructions to avoid potential hazards.
Other factors, such as underlying medical issues, could have had a role.
It’s worth noting that:
The study was observational, which means it cannot show that the combination of PDE5 inhibitors and nitrates caused premature death. Other factors, such as underlying medical issues, could have had a role.
Even for males who took both drugs, the absolute chance of dying young remained modest.
The study found no increased risk of death from cardiovascular disease, such as a heart attack or stroke.
If you are using both PDE5i medicines and nitrates, you should discuss the findings of this study with your doctor. They can help you understand your risk and decide if it is safe to continue taking both medications.
